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KMID : 1161420110140111383
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Journal of Medicinal Food
2011 Volume.14 No. 11 p.1383 ~ p.1388
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Chemical Study and Antimalarial, Antioxidant, and Anticancer Activities of Melaleuca armillaris (Sol Ex Gateau) Sm Essential Oil
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Chabir Naziha
Romdhane Mehrez
Valentin Alexis
Moukarzel Beatrice
Marzoug Hajer Naceur Ben
Brahim Nadia Ben
Mars Mohamed
Bouajila Jalloul
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Abstract
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This study investigated the chemical composition (by using gas chromatography/flame ionization detection and gas chromatography/mass spectrometry, an antioxidant [1,1-diphenyl-2-picrylhydrazyl] [DPPH] radical?scavenging assay, and a 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonate [ABTS] radical cation?scavenging assay) and the antimalarial and cytotoxic activities of essential oil extracted from leaves of Melaleuca armillaris. Thirty-two components representing more than 98% of the total composition of the essential oil were identified. The main components were 1,8-cineole (85.8%), camphene (5.05%), and α-pinene (1.95%). The antioxidant activity by ABTS assay showed a mean (±standard deviation) 50% inhibitory concentration (IC50) value of 247.3±3.9?mg/L, and the DPPH assay yielded an IC50 value of 2183.6±44.3?mg/L. The antimalarial study indicated that the essential oil had mild activity against the chloroquine-resistant Plasmodium falciparum FcB1 strain (IC50, 27±2?mg/L). The cytotoxic activity of this essential oil was tested against MCF7 human breast cancer cells and was found to be high (IC50, 12±1?mg/L).
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KEYWORD
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antimalarial, antioxidant, cytotoxic, essential oil, gas chromatography-mass spectrometry, Melaleuca
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